
Significant improvement
over the old neighbor.
The Big Bang Theory Season 1, Episode 1

I hear you owe that boy a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3

with his SIGNIFICANT other.
The Big Bang Theory Season 7, Episode 5

...I'm going to go do work
that promises SIGNIFICANT results...
The Big Bang Theory Season 2, Episode 2

Twenty thousand data runs
and no statistically SIGNIFICANT results.
The Big Bang Theory Season 2, Episode 13